Snail Dust: One girl. One mission. Survive everyday mediocrity.
Least I Could Do: One man. One mission. Get laid.
Spells and Whistles: One elf. One mission. Destroy the big evil thing.
Red vs. Blue: One webseries. One mission. Make us laugh.

The Art of Phil Fish: One man. One mission. Draw stuff, and occasionally make a funny short film.

Lobsterrags.com: The wonderfully odd art of a girl who sometimes goes by the name of Wonkie.
Bryy Miller.com: Brian's site.